Current Research
The primary interest of the Parthasarathy lab is in understanding how the peripheral auditory system and the central auditory pathway interact in various forms of hearing loss. The research program integrates study of human clinical populations and animal models using non-invasive, EEG-like evoked potentials as the translational bridge. The overall goal is to inform diagnosis and track the benefits of interventional therapies in clinical populations with hearing loss by utilizing insights obtained from animal models with similar forms of pathology.
Select Recent Publications
Chen JX, Whitton JP, Parthasarathy A, Hancock KE, Polley DB. Fluctuations in Subjective Tinnitus Ratings Over Time: Implications for Clinical Research. Otol Neurotol. 2020;41(9):e1167-e1173. doi:10.1097/MAO.0000000000002759
Parthasarathy A, Romero Pinto S, Lewis RM, Goedicke W, Polley DB. Data-driven segmentation of audiometric phenotypes across a large clinical cohort. Sci Rep. 2020;10(1):6704. Published 2020 Apr 21. doi:10.1038/s41598-020-63515-5
Lewis RM, Jahn KN, Parthasarathy A, Goedicke WB, Polley DB. Audiometric Predictors of Bothersome Tinnitus in a Large Clinical Cohort of Adults With Sensorineural Hearing Loss. Otol Neurotol. 2020;41(4):e414-e421. doi:10.1097/MAO.0000000000002568
Parthasarathy A, Hancock KE, Bennett K, DeGruttola V, Polley DB. Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing. Elife. 2020;9:e51419. Published 2020 Jan 21. doi:10.7554/eLife.51419
Parthasarathy A, Bartlett EL, Kujawa SG. Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation. Neuroscience. 2019;407:21-31. doi:10.1016/j.neuroscience.2018.12.007
Parthasarathy A, Herrmann B, Bartlett EL. Aging alters envelope representations of speech-like sounds in the inferior colliculus. Neurobiol Aging. 2019;73:30-40. doi:10.1016/j.neurobiolaging.2018.08.023
Parthasarathy A, Kujawa SG. Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing. J Neurosci. 2018;38(32):7108-7119. doi:10.1523/JNEUROSCI.3240-17.2018
Herrmann B, Parthasarathy A, Bartlett EL. Ageing affects dual encoding of periodicity and envelope shape in rat inferior colliculus neurons. Eur J Neurosci. 2017;45(2):299-311. doi:10.1111/ejn.13463