Current Research
Basic Science Research: Dr. Basura’s research interests include both basic science animal and human translational studies of tinnitus and single-sided deafness, both of which are challenging and common clinical problems. Using animal models of tinnitus and single-sided deafness, he has investigated multisensory integration (e.g., cross-modal plasticity of auditory cortex with somatosensory and visual systems) in the modulation of central auditory pathways following noise-induced tinnitus and single-sided deafness. His previous collaborations employed extracellular in vivo electrophysiology recordings to understand how non-auditory systems (e.g., somatosensory, and visual) modulate neural firing properties in auditory cortex neurons. This research helped to elucidate central neural origins of tinnitus percepts and brain plasticity following sudden unilateral (single-sided) deafness. Dr. Basura’s basic science work has been published in high-profile journals with numerous citations and has been funded by foundational (Deafness Research Foundation), governmental (NIH R03, R21) and clinical organizational (Clinician-Scientist Developmental Award sponsored by the American Otological Society) grant awards.
Clinical Research: Dr. Basura’s clinical/translational human research capitalizes on his basic science work and clinical practice expertise. He is currently using functional near-infrared spectroscopy (fNIRS), a type of non-invasive neuroimaging technology, to measure brain activity and plasticity in humans with tinnitus and single-sided deafness. This work has yielded several key seminal high-profile publications and many national and international presentations and a recently funded “high risk” NIH R21 grant for new technology development in collaboration with Biomedical/Electrical Engineering. The goal of this work is to advance existing fNIRS technology using highly innovative adaptations of the traditional fNIRS probes to gain better understanding of central auditory nervous system dysfunction to diagnose and treat disorders such as tinnitus and deafness that involve human central auditory circuits.
Selected Recent Publications
The Role of Academic Otolaryngology-Head and Neck Surgery in Global Health
OTO Open 2023
Mary Jue Xu, Rolvix Harlan Patterson, Joshua Wiedermann, Taseer Feroze Din, Samuel Okerosi, David A. Shaye, Andrew N. Goldberg, Samer Al-khudari, Gregory Basura, Robert M. Brody, Ryan Hale Belcher, Susan D. Emmett, Ashok Jagasia, Asitha Jayawardena, Walter T. Lee, Isaie Ncogozi, James Netterville, Jason G. Newman, Aslam Nkya, Brent A. Senior, Jeffrey D. Sharon, Mark G. Shrime, Travis Tollefson, Blake Alkire.
Multi-Sensory Integration in Brainstem and Auditory Cortex.
Brain Research (Invited article; Special Issue in Brain Research: Advances in the Neuroscience of Tinnitus) 2012.
Basura GJ, Koehler SD, Shore SE.
Clinical Practice Guideline: Bell’s Palsy Executive Summary.
Otolaryngology-Head and Neck Surgery 2013.
Baugh R, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, Deckard NA, Dawson C, Driscoll C, Gillespie MB, Gurgel RK, Halperin J, Khalid AN, Kumar KA, Micco A, Munsell D, Rosenbaum S, Vaughan W.
Comparison of Second-Echelon Treatments for Meniere’s disease.
JAMA Otolaryngology Head and Neck Surgery 2014.
Basura GJ, Lin GC, Telian SA.
Bimodal Stimulus Timing-Dependent Plasticity in Primary Auditory Cortex is Altered After Noise Exposure With and Without Tinnitus.
Journal of Neurophysiology 2015
Basura GJ, Koehler SD, Shore SE.
Functional Near-Infrared Spectroscopy Brain Imaging Investigation of Phonological Awareness and Passage Comprehension Abilities in Adult Recipients of Cochlear Implants.
Journal of Speech, Language, and Hearing Research 2016
Bisconti S, Shulkin M, Hu X, Basura GJ, Kileny P, and Kovelman I.
High ALDH Activity and CD44 Expression Identify Uniquely Tumorigenic Stem Cells in Salivary Mucoepidermoid Carcinoma.
Oncotarget 2015
Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura GJ, Helman J, Mantesso A, Castilho R, and Nor J.
Human Auditory and Adjacent Non-Auditory Cortices are Hyper-Metabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS).
Neural Plasticity 2016
Issa M, Bisconti S, Kovelman I, Kileny P, and Basura GJ.
Otolaryngology Outreach to Komfo Anokye Teaching Hospital: A Medical and Educational Partnership.
Journal of Laryngology and Otology 2017
Waller, B, Larsen-Reindorf R, Duah M, Edwards B, Brown D, Moyer, J, Prince M and Basura GJ.
Tinnitus Alters Resting State Functional Connectivity (RSFC) in Human Auditory and Non-Auditory Brain Regions as Measured by Functional Near-Infrared Spectroscopy (fNIRS).
PLOS One 2017
San Juan, J, Xiao-su H, Issa M, Bisconti S, Kovelman I, Kileny P, and Basura GJ.
Noise Exposure Alters Long-Term Neural Firing Rates and Synchrony in Primary Auditory and Rostral Belt Cortices Following Bimodal Stimulation.
Hearing Research 2017
Takacs J, Forrest T, Basura GJ.
Auditory-Somatosensory Stimulation Desynchronizes Brain Circuitry to Reduce Tinnitus in Guinea Pigs and Humans.
Science Translational Medicine 2018
Marks KL, Martel DT, Wu C, Basura GJ, Roberts LE, Schvartz-Leyzac KC, and Shore SE.
Human Central Auditory Plasticity; A Review of Functional Near-Infrared Spectroscopy (fNIRS) to Measure Cochlear Implant Performance and Tinnitus Perception.
Laryngoscope Investigative Otolaryngology 2018
Basura GJ, Xiao-Su H, San Juan J, Tessier AM, Kovelman I.
Portable Audiometric Screening Platforms Used in Low-Resourced Settings: A Review.
Journal of Laryngology and Otology 2018
Jayawardena A, Edwards B, Waller B, Larsen-Reindorf R, Esinam Anomah J, Frimpong B, Nondumiso AG, Netterville J, Saunders J and Basura GJ.
Skull Base, Hearing Preservation and Auditory Rehabilitation in Skull Base Surgery. Tinnitus Management.
Journal of Neurological Surgery 2019
San Juan J and Basura GJ.
Cholinergic Receptor Expression in Primary Auditory and Rostral Belt Cortices After Noise Damage.
Molecular Imaging 2019
Forrest TJ, Desmond TJ, Issa M, Scott PJH, and Basura GJ.
Pediatric Hearing loss: A Population-Based Survey in Peri-Urban Kumasi, Ghana.
Journal of Laryngology and Otology 2019
Larsen-Reindorf R, Otupiri E, Anomah JE, Edwards B, Frimpong B, Waller B, Prince M, Basura GJ.
Clinical Practice Guideline: Meniere’s Disease.
Otolaryngology-Head and Neck Surgery 2020
Basura GJ, Adams M, Monfared A, Schwartz S, Antonelli, Burkard R, Bush M, Bykowski J, Colandrea M, Kerber K, Koopman C, Angie A, Marcolini E, McKinnon B, Ruckenstein M, Valenzuela C, Vosooney A, Walsh S and Nnacheta L.
Tinnitus and Auditory Cortex; Using Adapted Functional Near-Infrared-Spectroscopy to Measure Resting State Functional Connectivity.
NeuroReport 2021
San Juan J, Zhai T, Ash-Rafzadeh A, Hu X, Kim J, Filipak C, Guo K, Islam M, Kovelman I, Basura GJ.
Tinnitus and Auditory Cortex; Using Adapted Functional Near-Infrared-Spectroscopy to Expand Brain Imaging in Humans.
Laryngoscope Investigative Otolaryngology 2020
Zhai T, Ash-Rafzadeh A, Xiao-Su H, Kim, J, San Juan J, Filipak C, Islam M, Kovelman I, Basura GJ.
Targeted Molecular Characterization of External Auditory Canal Squamous Cell Carcinomas.
Laryngoscope Investigative Otolaryngology 2021
Basura GJ, Smith JD, Ellsperman S, Bhangale A and Brenner JC.
Determining cochlear implant candidacy in adults: limitations, expansions, and opportunities for improvement.
Seminars in Hearing 2021
Zwolan T and Basura GJ.
A Step Towards Achieving Sustainable Otologic Surgery in Low-Resource Settings: A Cost Comparison Between Shipping an Otologic Versus Microscopic Surgical Setup.
Audiology Research 2022
Thompson R, Basura GJ, Din T and Jayawardena A.
American Speech-Language-Hearing Association Clinical Practice Guideline on Aural Rehabilitation for Adults with Hearing Loss.
American Journal of Audiology 2023
Basura GJ, Cienkowski K, Hamlin L, Christin R, Rutherford C, Stamper G, Schooling T, and Ambrose J.
Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial.
JAMA Network Open 2023
Jones G, Martel D, Riffle T, Errickson J, Souter J, Basura GJ, Stucken E, Schvartz-Leyzac K, Shore S.